Oncogenomics: Cross-species comparisons
نویسندگان
چکیده
منابع مشابه
Cross-Species Oncogenomics in Cancer Gene Identification
The complexity of genomic aberrations in most human tumors hampers delineation of the genes that drive the tumorigenic process. In this issue of Cell, and demonstrate that cognate mouse tumor models recapitulate these genetic alterations with unexpected fidelity. These results indicate that cross-species genomic analysis is a powerful strategy to identify the responsible genes and assess their ...
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SUMMARY To annotate newly sequenced organisms, cross-species sequence comparison algorithms can be applied to align gene sequences to the genome of a related species. To improve the accuracy of alignment, spaced seeds must be optimized for each comparison. As the number and diversity of genomes increase, an efficient alternative is to cluster pairwise comparisons into groups and identify seeds ...
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ژورنال
عنوان ژورنال: Nature Reviews Cancer
سال: 2006
ISSN: 1474-175X,1474-1768
DOI: 10.1038/nrc1962